The Eichel Lab seeks to understand how neurons build their elaborate polarized architecture. Neurons are extremely compartmentalized cells that must maintain the separation of hundreds of proteins in their distinct axonal and dendritic compartments. This polarized organization is essential for neuronal circuit formation and function. How neurons establish and maintain polarity is an enduring question in cellular and developmental neurobiology. We investigate this question using a C. elegans-to-human neuron cross-translational platform that provides both an in vivo model and a system to identify conserved mechanisms underlying neuronal polarity.

The lab will be opening in May 2024 in the Molecular, Cellular, and Developmental Biology Department at the University of Colorado Boulder.

Micrograph of neuron showing distinct subcompartments